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Peer Reviewed Publications : 2001-2008

  • Steed DL, Attinger C, Brem H, Colaizzi T, Crossland M, Franz M, Harkless L, Johnson A, Moosa H, Robson M, Serena T, Sheehan P, Veves A, Wiersma-Bryant L. Guidelines for the prevention of diabetic ulcers.Wound Repair Regen. 2008 Mar-Apr;16(2):169-74. No abstract available.
  • Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko M, Brem H, Tomic-Canic M. Deregulation of keratinocyte differentiation and activation: A hallmark of venous ulcers.J Cell Mol Med. 2008 Mar 28
  • Tomic-Canic M, Ayello E, Golinko M, Stojadinovic O, Brem H. Bar Coding a wound: a molecular guide to surgical debridement. Advances in Skin & Wound Care (2008).
  • Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes.
    J Clin Invest. 2007 May;117(5):1219-22. Review.
  • Brem H, Tomic-Canic M, Entero H, Hanflik AM, Wang VM, Fallon JT, Ehrlich HP. The synergism of age and db/db genotype impairs wound healing. Exp Gerontol. 2007 Jun;42(6):523-31. Epub 2007 Feb 1.
  • Brem H, Stojadinovic O, Diegelmann, RF, Entero H, Lee B, Pastar I, Golinko, M, Rosenberg H and Tomic-Canic M: Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement, (2007) Molecular Medicine Jan-Feb;13(1-2):30-9.
  • Hanflik A, Golinko M, Doft M, Cain C, Flattau A, Brem H. Operative Debridements of Chronic Wounds in Geriatric Persons. Eds. Jeffrey H. Silverstein, G. Alec Rooke,, J.G. Reves, Charles H. McLeskey. In Geriatric Anesthesia, 2nd Edition. New York. Springer, 2007.
  • Koo K, Brem H, Lebwohl M. Pyoderma gangrenosum versus chronic venous ulceration: comparison of diagnostic features. J Cutan Med Surg. 2006 Jan-Feb;10(1):26-30.
  • Brem H, Sheehan P, Rosenberg HJ, Schneider JS, Boulton AJ. Evidence-based protocol for diabetic foot ulcers. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):193S-209S; discussion 210S-211S. Review.
  • Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H, Tomic-Canic M. Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J Biol Chem. 2007 Feb 9;282(6):4021-34. Epub 2006 Nov 9.
  • Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J. Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol. 2006;26(5):430-6. Epub 2006 Sep 13.
  • Lee B, Vouthounis C, Stojadinovic O, Brem H, Im MJ, Tomic-Canic M. From an Enhanceosome to a Repressosome: Molecular Antagonism between Glucocorticoids and EGF Leads to Inhibition of Wound Healing. Journal of Molecular Biology. .2005; 345(5):1083-97.
  • Brem H, Kirsner RS, Falanga V: Protocol for the successful treatment of venous ulcers. American Journal of Surgery. 2004;188: 1-8.
  • Wallenstein S, Brem H: Statistical analysis of wound healing rates for pressure ulcers. American Journal of Surgery. 2004;188: 73-8.
  • Tomic-Canic M, Brem H: Gene array technology and pathogenesis of chronic wounds. American Journal of Surgery. 2004;188: 67-72.
  • Freedman G, Brem H: Practical treatment of pain in patients with chronic wounds: a pathogenesis-guided management. American Journal of Surgery. 2004;188: 31-5.
  • Brem H, Lyder C: Protocol for successful treatment of pressure ulcers. American Journal of Surgery. 2004;188: 9-17.
  • Brem H, Sheehan P, Boulton AJM: Protocol for the treatment of diabetic foot ulcers. American Journal of Surgery. 2004;187:1-10.
  • Brem H, Gill K, Tarnovskaya A, Ehrlich HP, Carasa M, Weinberger S, Baskin-Bey E, Tomic-Canic M, Vladeck B. Healing of Elderly Patients with Diabetic Foot Ulcers, Venous Stasis Ulcers, and Pressure Ulcers. Surgery Technology International. 2003; XI: 161-167.
  • Peppa M, Brem H, Zhang J, Cai W, Vlassara H. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 2003 Nov;52(11):2805-13.
  • Freedman G, Cean C, Duron V, Tarnovskaya A, and Brem H. Pathogenesis and Treatment of Pain in Patients with Chronic Wounds. Surgery Technology International. 2003; XI: 23-31 168-182.
  • Brem H, Jacobs T, Vileikyte L, Weinberger S, Gibber M, Boulton A. Wound Healing Protocols for Diabetic Foot and Pressure Ulcers. Surgery Technology International. 2003; XI: 85-96.
  • Brem H, Young J, Tomic-Canic M, Isaacs C, Ehrlich, H.P. Clinical Efficacy and Mechanism of Bilayered Living Human Skin Equivalent in the Treatment of Diabetic Foot Ulcers. Surgery Technology International. 2003; XI: 23-31.
  • Willis A, Gibber M, Moore S, Brem H. Sickle Cell Disease and Leg Ulcers: Pathogenesis, Complications, Assessment, and Treatment. In Wound Care Essentials, ed. by Elizabeth Ayello and Sharon Baronski. 2003.
  • Brem H, Nelson J, Nierman, D: Treatment of Pressure Ulcers in the Intensive Care Unit. Critical Care Clinics of North America, 2002;Vol.18, issue 3:1-12.
  • Brem H. Specific Paradigm for Wound Bed Preparation in Chronic Wounds. In Cherry GW, Harding KG, Ryan TJ, Editors. Wound Bed Preparation. The Royal Society of Medicine Press Ltd. University of Oxford, UK. 2001; 33-39.
  • Falanga V, Brem H. Wound Bed Preparation for Optimal Use of Advanced Therapeutic Products. In Falanga V, Editor. Cutaneous Wound Healing. Boston University Press, 2001; 457-468.
  • Brem H, Balledux J, Sukkarieh T, Falanga V. Healing of Venous Ulcers of long Duration with a Bilayered Living Skin Substitute: Results from a General Surgery and Dermatology Department. Dermatologic Surgery. 2001 Nov; 27(11):915-9.
  • Brem H, and Kirsner R. Use of Graftskin in the Treatment of Pressure Ulcers and Acute Wounds. Wounds 2000; 12:72-77.
  • Brem H, Balledux J, Bloom T, Kerstein M, Hollier L: Healing of diabetic ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing. Archives of Surgery 2000;135:627-634.
  • Rosser JC, Prosst RL, Rodas EB, Rosser LE, Murayama M, Brem H. Evaluation of the Effectiveness of Portable Low-Bandwidth Telemedical Applications for Postoperative Followup: Initial Results. J Am Coll Surg. 2000 Aug:191(2):196-203.
  • Accepted Abstracts: 2007-2008
    Marjana Tomic-Canic, Elizabeth A. Ayello, Olivera Stojadinovic, Irena Pastar, Sasa Vukelic, Michael S. Golinko, and Harold Brem. Using gene transcription patterns to guide the extent of excisional debridment of chronic wounds. Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Pastar I., Stojadinovic, O, Barrientos S., Krzyzanowska, A., Brem, H, Vukelic S, Golinko M, and Tomic-Canic, M Biological Characterization of Epidermis of Chronic Wounds. Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Stephan Barrientos, Olivera Stojadinovic, Michael Golinko, Eashwar B. Chandrasekaran, Harold Brem and Marjana Tomic-Canic Molecular Markers of Pathogenesis of Chronic Wounds Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Olivera Stojadinovic, Asheesh Harsha, Harold Brem, Carl P. Blobel, Marjana Tomic-Canic ADAM12: a potential target for treatment of chronic wounds. Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Vukelic S, Krzyzanowska A, Stojadinovic O, Pastar I, Golinko M3Brem H, Rabach M, and Tomic-Canic M Epidermal Cortisol Synthesis Inhibits Wound Healing Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Michael S. Golinko , Andrew M. Hanflik , Marjana Tomic, Vincent M. Wang , Hyacinth Entero , Harvey Rosenberg , John Fallon , H.Paul Ehrlich and Harold Brem. Synergy of Diabetes and Aging Impairs Wound Healing. Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Michael S. Golinko , Eashwar Chandrasekaran, Dave Kaplan and Harold Brem. Development of a Relational Databank for Chronic Wounds Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Michael S. Golinko , Jessica Schiffman, Eashwar Chandrasekaran , Anna Flattau , Robert Rennert , Olivera Stojadinovic , Stephan Barrientos , Marjana Tomic-Canic and Harold Brem . Operative Technique for Debridement of Severe Pressure Ulcers Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Olivera Stojadinovic, Arber Kodra, Michael Golinko, Marjana Tomic-Canic, Harold Brem . Adenovirus-mediated Local Release of GM-CSF Promotes Repair in Diabetic Mice Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Harold Brem, Michael S. Golinko, Olivera Stojadinovic, Arber Kodra, Robert F. Diegelmann, Sasa Vukelic, Hyacinth Entero, Donald Coppock and Marjana Tomic-Canic Primary cultured fibroblasts derived from patients with chronic wounds: New cell lines available to the research community. Abstract presented at the 3rd Annual World Union of Wound Healing Societies 2008.
  • Michael Golinko, Eashwar Chandrasekaran, Dalton Cox, Harold Brem. A novel relational database for clinical outcomes in patients with diabetic foot ulcers: The Wound Electronic Medical Record (WEMR). Accepted to the American College of Surgeons Clinical Congress Surgical Forum 2008.
  • Eashwar Chandrasekan MS, Michael S. Golinko MD, MA, Dalton Cox, Vukelic Sasa MD, Renata Joffe MD, Olivera Stojadinovic MD, Marjana Tomic- Canic ,PhD, Harold Brem, MD Surgical Pathology to define margin of debridement of Diabetic Foot Ulcers. Accepted to the American College of Surgeons Clinical Congress Surgical Forum 2008.
    Hyacinth Entero; Arber Kodra; Vincent Wang, PhD; Michael Golinko, MD; Marjana Tomic, PhD; Paul Ehrlich, PhD; Harold Brem, MD VEGF enhances angiogenic response in experimental wounds as measured by tensile properties of the wound, increased epithelialization, and decreased time to closure. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007.
    Joshua Gordon, Anna Flattau, MD, Arber Kodra and Harold Brem, MD. The wound alert system: an informatics intervention in wound healing. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007.
  • Jessica Schiffman, Michael Golinko, MD, Anna Flattau, MD, Robert Rennert, Harold Brem, MD . Operative technique for debridement of pressure ulcers. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007.
  • Entero Hyacinth, Marjana Tomic-Canic , Andrew M. Hanflik, Michael Golinko , Vincent M. Wang, John Fallon , H. Paul Ehrlich, and Harold Brem Hyperglycemia doesn't significantly impair tensile strength in wounds of diabetic mice. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54
  • Coppock, D.L.Tomic-Canic, M., Stojadinovic, O. , Ehrlich,HP and Diegleman, R., Golinko, M., Brem, H. Development of a national institute on aging cell repository for fibroblast cell lines from patients with venous ulcers. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54
  • Stojadinovic, O, Brem, H, Vukelic S, Pastar I, Carucci J, Golinko M, Martinez L, Rennert R and Tomic-Canic, M Deregulation of keratinocyte differentiation and
    activation pathways in chronic wounds. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Olivera Stojadinovic; MarjanaTomic-Canic; Michael Golinko; Harold Brem GMCSF stimulates migration of activated keratinocytes and fibroblasts from patients with chronic wounds. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Tomic-Canic, M., Stojadinovic, O. , Ehrlich,HP and Diegleman, R., Golinko, M., Coppock, D.L., Brem, H. Development of fibroblast cell lines from patients with venous ulcers for the NIA aging cell repository. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Kapil-Pair, N; Rennert R.; Golinko, M, Kaplan, D; Brem, H Preventing Stage IV pressure ulcers utilizing a simultaneous treatment protocol. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Pastar I, Stojadinovic O, Vukelic S, Golinko M, Rosenberg H, Brem H, Tomic-Canic M. Calcium-mediated keratinocyte differentiation reveals changes in chronic wound keratinocyte phenotype. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Stojadinovic, O; Kodra, A ; Golinko M; Tomic-Canic, M ; Brem, H A novel-non-angiogenic mechanism of VEGF: stimulation of keratinocyte and fibroblast migration. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.
  • Vukelic S, Stojadinovic O, Rabach M, Brem H, Pastar I, LaBruna A,Golinko M, Martinez L, Vouthounis G,and Tomic-Canic M Glucocorticoids: de novo steroidogenesis in skin contributes to pathogenesis of chronic wounds. Abstract presented at the Annual Symposium on Advanced Wound Care. Wound Healing Society Meeting, 2007. Wound Repair Regen (2007) March-April 15:A13-54.